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1

Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps

Nadezhda German, Peng Wei, Glenn W. Kaatz, Robert J. Kerns

Journal:

European Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 325 KB

english, 2008

2

From Phenothiazine to 3-Phenyl-1,4-benzothiazine Derivatives as Inhibitors of the Staphylococcus aureus NorA Multidrug Efflux Pump

Sabatini, Stefano, Kaatz, Glenn W., Rossolini, Gian Maria, Brandini, David, Fravolini, Arnaldo

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 208 KB

english, 2008

3

Searching for Novel Inhibitors of the S. aureus NorA Efflux Pump: Synthesis and Biological Evaluation of the 3-Phenyl-1,4-benzothiazine Analogues

Felicetti, Tommaso, Cannalire, Rolando, Burali, Maria Sole, Massari, Serena, Manfroni, Giuseppe, Barreca, Maria Letizia, Tabarrini, Oriana, Schindler, Bryan D., Sabatini, Stefano, Kaatz, Glenn W, Cecc

Journal:

Year:

2017

Language:

english

File:

PDF, 1.63 MB

english, 2017

4

Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates

Mire Zloh, Glenn W. Kaatz, Simon Gibbons

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 226 KB

english, 2004

5

Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps

Peng Wei, Glenn W. Kaatz, Robert J. Kerns

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 285 KB

english, 2004

6

N-Caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors

Serge Michalet, Gilbert Cartier, Bruno David, Anne-Marie Mariotte, Marie-Geneviève Dijoux-franca, Glenn W. Kaatz, Michael Stavri, Simon Gibbons

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 152 KB

english, 2007

7

Synthesis and evaluation of PSSRI-based inhibitors of Staphylococcus aureus multidrug efflux pumps

Nadezhda German, Glenn W. Kaatz, Robert J. Kerns

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 205 KB

english, 2008

8

Antibacterials and modulators of bacterial resistance from the immature cones of Chamaecyparis lawsoniana

Eileen C.J. Smith, Elizabeth M. Williamson, Neale Wareham, Glenn W. Kaatz, Simon Gibbons

Journal:

Year:

2007

Language:

english

File:

PDF, 176 KB

english, 2007

9

Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureus

Robert J Kerns, Michael J Rybak, Glenn W Kaatz, Flamur Vaka, Raymond Cha, Richard G Grucz, Veena U Diwadkar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 151 KB

english, 2003

10

Antibacterial and resistance modifying activity of Rosmarinus officinalis

Moyosoluwa Oluwatuyi, Glenn W. Kaatz, Simon Gibbons

Journal:

Year:

2004

Language:

english

File:

PDF, 298 KB

english, 2004

11

Piperazinyl-linked fluoroquinolone dimers possessing potent antibacterial activity against drug-resistant strains of Staphylococcus aureus

Robert J. Kerns, Michael J. Rybak, Glenn W. Kaatz, Flamur Vaka, Raymond Cha, Richard G. Grucz, Veena U. Diwadkar, Tracey D. Ward

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 167 KB

english, 2003

12

From 6-Aminoquinolone Antibacterials to 6-Amino-7-thiopyranopyridinylquinolone Ethyl Esters as Inhibitors of Staphylococcus aureus Multidrug Efflux Pumps

Pieroni, Marco, Dimovska, Mirjana, Brincat, Jean Pierre, Sabatini, Stefano, Carosati, Emanuele, Massari, Serena, Kaatz, Glenn W., Fravolini, Arnaldo

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 1.14 MB

english, 2010

13

Antimicrobial Susceptibility and Staphylococcal Chromosomal Cassette mec Type in Community- and Hospital-Associated Methicillin-Resistant Staphylococcus aureus

Kerry L. LaPlante, Michael J. Rybak, Muhammad Amjad, Glenn W. Kaatz

Journal:

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Year:

2007

Language:

english

File:

PDF, 97 KB

english, 2007

14

Treatment strategies for infective endocarditis

Chopra, Teena, Kaatz, Glenn W

Journal:

Expert Opinion on Pharmacotherapy

Year:

2010

Language:

english

File:

PDF, 683 KB

english, 2010

15

Inhibitors of Bacterial Multidrug Efflux Pumps from the Resin Glycosides of Ipomoea murucoides⊥

Chérigo, Lilia, Pereda-Miranda, Rogelio, Fragoso-Serrano, Mabel, Jacobo-Herrera, Nadia, Kaatz, Glenn W., Gibbons, Simon

Journal:

Journal of Natural Products

Year:

2008

Language:

english

File:

PDF, 146 KB

english, 2008

16

Successful therapy of pseudomonas aeruginosa endocarditis with ceftazidime and tobramycin

Antonio E. Cabinian, Glenn W. Kaatz

Journal:

The American Journal of Medicine

Year:

1987

Language:

english

File:

PDF, 269 KB

english, 1987

17

Clinical isolates of Staphylococcus aureus from 1987 and 1989 demonstrating heterogeneous resistance to vancomycin and teicoplanin

Michael J. Rybak, Raymond Cha, Chrissy M. Cheung, Venkata G. Meka, Glenn W. Kaatz

Journal:

Diagnostic Microbiology and Infectious Disease

Year:

2005

Language:

english

File:

PDF, 232 KB

english, 2005

18

Community- and health care-associated methicillin-resistant Staphylococcus aureus: a comparison of molecular epidemiology and antimicrobial activities of various agents

Brian T. Tsuji, Michael J. Rybak, Chrissy M. Cheung, Muhammad Amjad, Glenn W. Kaatz

Journal:

Diagnostic Microbiology and Infectious Disease

Year:

2007

Language:

english

File:

PDF, 280 KB

english, 2007

19

In vitro activities of mutant prevention concentration-targeted concentrations of fluoroquinolones against Staphylococcus aureus in a pharmacodynamic model

George P Allen, Glenn W Kaatz, Michael J Rybak

Journal:

International Journal of Antimicrobial Agents

Year:

2004

Language:

english

File:

PDF, 178 KB

english, 2004

20

Mechanisms of daptomycin resistance in Staphylococcus aureus

Glenn W. Kaatz, Tammy S. Lundstrom, Susan M. Seo

Journal:

International Journal of Antimicrobial Agents

Year:

2006

Language:

english

File:

PDF, 184 KB

english, 2006

21

Inability of a reserpine-based screen to identify strains overexpressing efflux pump genes in clinical isolates of Staphylococcus aureus

Emmanuel Frempong-Manso, Jose L. Raygada, Carmen E. DeMarco, Susan M. Seo, Glenn W. Kaatz

Journal:

International Journal of Antimicrobial Agents

Year:

2009

Language:

english

File:

PDF, 117 KB

english, 2009

22

Evaluation of dalbavancin, tigecycline, minocycline, tetracycline, teicoplanin and vancomycin against community-associated and multidrug-resistant hospital-associated meticillin-resistant Staphylococcus aureus

Vanthida Huang, Chrissy M. Cheung, Glenn W. Kaatz, Michael J. Rybak

Journal:

International Journal of Antimicrobial Agents

Year:

2010

Language:

english

File:

PDF, 229 KB

english, 2010

23

In silico genetic correlations of multidrug efflux pump gene expression in Staphylococcus aureus

Christos Kosmidis, Carmen E. DeMarco, Emmanuel Frempong-Manso, Susan M. Seo, Glenn W. Kaatz

Journal:

International Journal of Antimicrobial Agents

Year:

2010

Language:

english

File:

PDF, 204 KB

english, 2010

24

Mechanisms of in-vitro-selected daptomycin-non-susceptibility in Staphylococcus aureus

Diixa Patel, Mashkur Husain, Celine Vidaillac, Molly E. Steed, Michael J. Rybak, Susan M. Seo, Glenn W. Kaatz

Journal:

International Journal of Antimicrobial Agents

Year:

2011

Language:

english

File:

PDF, 313 KB

english, 2011

25

Expression of multidrug resistance efflux pump genes in clinical and environmental isolates of Staphylococcus aureus

Christos Kosmidis, Bryan D. Schindler, Pauline L. Jacinto, Diixa Patel, Karanpreet Bains, Susan M. Seo, Glenn W. Kaatz

Journal:

International Journal of Antimicrobial Agents

Year:

2012

Language:

english

File:

PDF, 228 KB

english, 2012

26

Phenylpiperidine selective serotonin reuptake inhibitors interfere with multidrug efflux pump activity in Staphylococcus aureus

Glenn W Kaatz, Varsha V Moudgal, Susan M Seo, John Bondo Hansen, Jette E Kristiansen

Journal:

International Journal of Antimicrobial Agents

Year:

2003

Language:

english

File:

PDF, 325 KB

english, 2003

27

Inhibition of drug efflux pumps in Staphylococcus aureus : current status of potentiating existing antibiotics

Schindler, Bryan D, Jacinto, Pauline, Kaatz, Glenn W

Journal:

Future Microbiology

Year:

2013

Language:

english

File:

PDF, 910 KB

english, 2013

28

Pyrazolo[4,3- c ][1,2]benzothiazines 5,5-Dioxide: A Promising New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors

Sabatini, Stefano, Gosetto, Francesca, Serritella, Serena, Manfroni, Giuseppe, Tabarrini, Oriana, Iraci, Nunzio, Brincat, Jean Pierre, Carosati, Emanuele, Villarini, Milena, Kaatz, Glenn W., Cecchetti

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.49 MB

english, 2012

29

Re-evolution of the 2-Phenylquinolines: Ligand-Based Design, Synthesis, and Biological Evaluation of a Potent New Class of Staphylococcus aureus NorA Efflux Pump Inhibitors to Combat Antimicrobial Resistance

Sabatini, Stefano, Gosetto, Francesca, Iraci, Nunzio, Barreca, Maria Letizia, Massari, Serena, Sancineto, Luca, Manfroni, Giuseppe, Tabarrini, Oriana, Dimovska, Mirjana, Kaatz, Glenn W., Cecchetti, Vi

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 2.94 MB

english, 2013

30

Searching for innovative quinolone-like scaffolds: synthesis and biological evaluation of 2,1-benzothiazine 2,2-dioxide derivatives

Pieroni, Marco, Sabatini, Stefano, Massari, Serena, Kaatz, Glenn W., Cecchetti, Violetta, Tabarrini, Oriana

Journal:

Year:

2012

Language:

english

File:

PDF, 216 KB

english, 2012

31

Inhibition of bacterial efflux pumps: a new strategy to combat increasing antimicrobial agent resistance

Journal:

Expert Opinion on Emerging Drugs

Year:

2002

Language:

english

File:

PDF, 207 KB

english, 2002

32

Evolution from a Natural Flavones Nucleus to Obtain 2-(4-Propoxyphenyl)quinoline Derivatives As Potent Inhibitors of the S. aureus NorA Efflux Pump

Sabatini, Stefano, Gosetto, Francesca, Manfroni, Giuseppe, Tabarrini, Oriana, Kaatz, Glenn W., Patel, Diixa, Cecchetti, Violetta

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.88 MB

english, 2011

33

Polyacylated Oligosaccharides from Medicinal Mexican Morning Glory Species as Antibacterials and Inhibitors of Multidrug Resistance in Staphylococcus aureus ⊥

Pereda-Miranda, Rogelio, Kaatz, Glenn W., Gibbons, Simon

Journal:

Journal of Natural Products

Year:

2006

Language:

english

File:

PDF, 166 KB

english, 2006

34

Evaluation of Daptomycin Non-SusceptibleStaphylococcus aureusfor Stability, Population Profiles,mprFMutations, and Daptomycin Activity

Steed, Molly E., Hall, Ashley D., Salimnia, Hossein, Kaatz, Glenn W., Kaye, Keith S., Rybak, Michael J.

Journal:

Infectious Diseases and Therapy

Year:

2013

Language:

english

File:

PDF, 515 KB

english, 2013

35

Discovery of Novel Inhibitors of the NorA Multidrug Transporter of Staphylococcus aureus

Brincat, Jean Pierre, Carosati, Emanuele, Sabatini, Stefano, Manfroni, Giuseppe, Fravolini, Arnaldo, Raygada, Jose L., Patel, Diixa, Kaatz, Glenn W., Cruciani, Gabriele

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 3.58 MB

english, 2011

36

Crystal Structure of a MepR-DNA Complex Reveals the Mechanism of Transcription Repression of S. Aureus Multidrug Efflux Pump mepA

Birukou, Ivan, Kaatz, Glenn W., Brennan, Richard G.

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 36 KB

english, 2013

37

Characteristics of Patients With Healthcare‐Associated Infection Due to SCCmecType IV Methicillin‐ResistantStaphylococcus aureus •

Davis, Susan L., Rybak, Michael J., Amjad, Muhammad, Kaatz, Glenn W., McKinnon, Peggy S.

Journal:

Infection Control and Hospital Epidemiology

Year:

2006

Language:

english

File:

PDF, 257 KB

english, 2006

38

The emergence of resistance to ciprofloxacin during treatment of experimental Staphylococcus aureus endocarditis

Kaatz, Glenn W., Barriere, Steven L., Schaberg, Dennis R., Fekety, Robert

Journal:

Journal of Antimicrobial Chemotherapy

Year:

1987

Language:

english

File:

PDF, 287 KB

english, 1987

39

Ligand Promiscuity between the Efflux Pumps Human P-Glycoprotein and S. aureus NorA

Brincat, Jean Pierre, Broccatelli, Fabio, Sabatini, Stefano, Frosini, Maria, Neri, Annalisa, Kaatz, Glenn W., Cruciani, Gabriele, Carosati, Emanuele

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 685 KB

english, 2012

40

Correction to From 6-Aminoquinolone Antibacterials to 6-Amino-7-thiopyranopyridinylquinolone Ethyl Esters as Inhibitors of Staphylococcus aureus Multidrug Efflux Pumps

Pieroni, Marco, Dimovska, Mirjana, Brincat, Jean Pierre, Sabatini, Stefano, Carosati, Emanuele, Massari, Serena, Kaatz, Glenn W., Fravolini, Arnaldo

Journal:

Journal of Medicinal Chemistry

Year:

2011

File:

PDF, 840 KB

2011

41

Analyses of Multidrug Efflux Pump-Like Proteins Encoded on the Staphylococcus aureus Chromosome: TABLE 1

Schindler, Bryan D., Frempong-Manso, Emmanuel, DeMarco, Carmen E., Kosmidis, Christos, Matta, Varun, Seo, Susan M., Kaatz, Glenn W.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 150 KB

english, 2015

42

Mutations within the mepA Operator Affect Binding of the MepR Regulatory Protein and Its Induction by MepA Substrates in Staphylococcus aureus

Schindler, Bryan D., Seo, Susan M., Birukou, Ivan, Brennan, Richard G., Kaatz, Glenn W., Schneewind, O.

Journal:

Journal of Bacteriology

Year:

2015

Language:

english

File:

PDF, 4.05 MB

english, 2015

43

Clonal relatedness is a predictor of spontaneous multidrug efflux pump gene overexpression in Staphylococcus aureus

Schindler, Bryan D., Jacinto, Pauline L., Buensalido, Joseph Adrian L., Seo, Susan M., Kaatz, Glenn W.

Journal:

International Journal of Antimicrobial Agents

Year:

2015

Language:

english

File:

PDF, 439 KB

english, 2015

44

Activity of ampicllin plus sulbactam against-βlactamase producing enterococci in experimental endocarditis

THAL, LEE ANN, VAZQUEZ, JOSE, PERRI, MARY BETH, BECKLEY, ANN, KAATZ, GLENN W., PATTERSON, JAN EVANS, ZERVOS, MARCUS J.

Journal:

Journal of Antimicrobial Chemotherapy

Year:

1993

Language:

english

File:

PDF, 287 KB

english, 1993

45

Antibacterial Sesquiterpenoid Derivatives from Ferula ferulaeoides

Liu, Tao, Osman, Khadijo, Kaatz, Glenn, Gibbons, Simon, Mu, Qing

Journal:

Year:

2013

Language:

english

File:

PDF, 203 KB

english, 2013

46

Catechin Gallates Inhibit Multidrug Resistance (MDR) in Staphylococcus aureus

Gibbons, Simon, Moser, Elisabeth, Kaatz, Glenn W.

Journal:

Year:

2004

Language:

english

File:

PDF, 64 KB

english, 2004

47

Oxazolidinones: new players in the battle against multi-resistant Gram-positive bacteria

Kaatz, Glenn W, Rybak, Michael J

Journal:

Expert Opinion on Emerging Drugs

Year:

2001

Language:

english

File:

PDF, 371 KB

english, 2001

48

Indole based weapons to fight antibiotic resistance: a structure-activity relationship study

Lepri, Susan, Buonerba, Federica, Goracci, Laura, Velilla, Irene, Ruzziconi, Renzo, Schindler, Bryan D., Seo, Susan M., Kaatz, Glenn W, Cruciani, Gabriele

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1.57 MB

english, 2016

49

Benzocyclohexane Oxide Derivatives and Neolignans from Piper betle Inhibit Efflux-Related Resistance in Staphylococcus aureus

Sun, Zhong-Lin, He, Jian-Ming, Wang, Shuang-Ying, Ma, Ru, Khondkar, Proma, Kaatz, Glenn W., Gibbons, Simon, Mu, Qing

Journal:

Year:

2016

Language:

english

File:

PDF, 1.67 MB

english, 2016

50

Multidrug Efflux Pumps of Gram-Positive Bacteria

Schindler, Bryan D., Kaatz, Glenn W.

Journal:

Drug Resistance Updates

Year:

2016

Language:

english

File:

PDF, 1.14 MB

english, 2016

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